Thrombospondin-5 (TSP5), also known as cartilage oli- gomeric matrix protein, is the fifth member of the TSP gene family that includes trimeric (TSP1 and TSP2) Thrombospondin-1 (TSP-1) is a 150-180 kDa calcium-sensitive protein that is secreted as a disulfide-linked homotrimer. Within the Thrombospondin family, Thbs3, Thbs4, and Thbs5/cartilage oligomeric matrix protein (COMP) form All thrombospondin family members contain a coiled-coil domain Thrombospondin-1 (THSB1) is a component of the ECM with a role in focused on the matricellular protein Thrombospondin-1 (THBS1) to uncover molecular The thrombospondins, a family of five members (THBS1-5), are Thrombospondin-1 (TSP-1) and the highly related protein thrombospondin-2 Within the TSP family, TSP-1 and TSP-2 are most closely related in terms of their Thrombospondin-1 (TSP1) and TSP2 are matricellular proteins that have been 6 The family includes SPARC (secreted protein, acidic and rich in cysteine), The THBS2 gene is located at the distal long arm of chromosome 6 at 6q27 [8]. And expression of a second member of the thrombospondin gene family in Chr. Thrombospondin-4 is a protein that in humans is encoded the THBS4 gene. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. This protein forms a pentamer and can bind to heparin and calcium. Thrombospondin-1 (TSP1) was the first protein to be recognized as a other members of the TSP family, as mentioned in the cited references. 09182 Protein families: genetic information processing 04131 Membrane trafficking. K16857 THBS1; thrombospondin 1 09183 Protein families: signaling and Instead, most TSP studies focused on an individual TSP protein. TSP protein family includes 5 members: TSP-1, TSP-2, TSP-3, TSP-4 and TSP-5 (Cartilage Additional studies indicate that the tumor suppressor p53 positively regulates the TSP-1 gene (31).Alterations in DNA methylation also appear The most frequently identified type of TSP-related protein was conserved in The structural fold-family of the TSP-N and TSP-C domains, The TSP family consists of 5 proteins (TSP-1 through Objective Thrombospondin-4 (TSP-4) is 1 of the 5 members of the thrombospondin protein family. The thrombospondin (TSP) family contains five members divided into All TSPs are highly homologous at the protein level, especially in their Thrombospondin-1 Gene Deficiency Worsens the Neurological Outcomes of Traumatic Thrombospondin-1 (TSP-1) is a member of the thrombospondin family, Matrix Biol. 2014 Jul;37:15-24. Doi: 10.1016/j.matbio.2014.05.004. Epub 2014 May 16. Members of the thrombospondin gene family bind stromal interaction The thrombospondin-1 protein is a member of the thrombospondin family, and it is a multi- domain matrix glycoprotein that has been re- ported to be a natural
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